How to Change Your Mind

Prologue: A New Door

• Lysergic acid diethylamide, commonly known as LSD, was first synthesized by Albert Hofmann in 1938, shortly before physicists split an atom of uranium for the first time.
• Psilocybin had been around for thousands of years, though no one in the developed world was amare of it.
• The impact of these two molecules is hard to overestimate. The advent of LSD can be linked to the revolution in brain science that begins in the 1950s, when scientists discovered the role of neurotransmitters in the brain. that quantities of LSD measured in micrograms could produce symptoms resembling psychosis inspired brain scientists to search for the neurochemical basis of mental disorders previously believed to be psychological in origin.
• Compared with other drugs, psychedelics seldom affect people the same way twice, because they tend to magnify whatever's already going on both inside and outside one's head.
• LSD appears to disable such conventionalized, shorthand modes of perception and, by doing so, restores a childlike immediacy, and sense of wonder, to our experience of reality, as if we were seeing everything for the first time.
• The Hopkins study demonstrated that a high dose of psilocybin could be used to safely and reliably "occasion" a mystical experience - typically described as the dissolution of one's ego followed by a sense of merging with the universe.
• There is not a culture of earth (except the Inuit) that doesn't make use of certain plants to change the contents of the mind, whetheras a matter of healing, habit, or spiritual practice.
• Shaking the snow globe - Over time, we tend to optimize and conventionalize our responses to whatever life brings. Each of us develops our shorthand ways of slotting and processing everyday experiences and solving problems, and while this is no doubt adaptive - it helps us get the job done with a minimum of fuss - eventually it becomes rote. It dulls us. The muscles of attention atrophy.
• Habits are undeniably useful tools, relieving us of the need to run a complex mental operation every time we're confronted with a new task or situation. Yet they also relieve us of the need to stay awake to the world: to attend, feel, think, and then act in a deliberate manner. (That is, from freedom rather than compulsion.) If you need to be reminded how completely mental habit blinds us to experience, just take a trip to an unfamiliar country. Suddenly you wake up! And the algorithms of everyday life all but start over, as if from scratch. This is why the various travel metaphors for the psychedelic experience are so apt.
• We approach experience much as an AI program does, with our brains continually translating the data of the present into the terms of the past, reaching back in time for the relevant experience, and then using that to make its best guess as to how to predict and navigate the future.
• One of the things that commends travel, art, nature, work, and certain drugs to us is the way these experiences, at their best, block every mental path forward and back, immersing us in the flow of a present that is literally wonderful - wonder being the by-product of precisely the kind of unencumbered first sight, or virginal noticing, to which the adult brain has closed itself. (It's so inefficient!)

1. A Renaissance

• LSD is one of the most powerful psychoactive compounds ever discovered, active at doses measured in micrograms (1/1000 of a milligram)
• Today, LSD devotees celebrate "Bicycle Day" each year on April 19 after Hofmann cycled home on acid.
• The Good Friday or Marsh Chapel Experiment in 1962, conducted by Walter Pahnke. 10 divinity students are given psilocybin and 10 an "active placebo". Pahnke concluded that the experiences of those who received the psilocybin were indistinguishable from, if not identical with the classic mystical experiences reported in the literature.
• Grof: Psychedlics "would be for psychiatry what the microscope is for biology or the telescope is for astronomy. These tools make it possible to study important processes that under normal circumstances are not available for direct observation.
• Bob Richards: "You go deep enough or far out enough in consciousness and you will bump into the sacred. It's not something we generate; it's something out there waiting to be discovered. And this reliably happens to nonbelievers as well as believers."
• Whether occasioned by drugs or other means, these experiences of mystical consciousness are in all likelihood the primal basis of religion.
• Boothby: "I felt all my organizing categories of opposition - dreaming and wakefulness, life and death, inside and outside, self and other - collapse into each other... Reality appeared to fold in on itself, to implode in a kind of ecstatic catastrophe of logic. Yet in the midst of this hallucinatory hurricane I was having a weird experience of ultra-sublimity. And I remember repeating to myself again and again, 'Nothing matters, nothing matters any more. I see the point! Nothing matters at all.'"
• James' marks indicating a mystical experience:
  • Ineffability - The subject immediately says that it defies expression, that no adequate report of its contents can be given in words.
  • Noetic - Mystical states seem to those who experience them to be also states of knowledge... They are illuminations, revelations full of significance and importance... and as a rule they carry with them a curious sense of authority.
  • Transiency - The mystical experience cannot be sustained for long, but its traces persist and recur.
  • Passivity - The mystic feels as if his own will were in abeyance, and indeed sometimes as if he were grasped and held by a superior power. The person may feel as if they have been permanently transformed.
• Boothby: "Our task in life consists precisely in a form of letting go of fear and expectations, an attempt to purely give oneself to the impact of the present.
• John Hayes: "sense of the concrete destabilized".
• James: "It is as if the opposites of the world, whose contradictoriness and conflict make all our difficulties and troubles, were melted into unity." This ultimate unity, he suspected, was no mere delusion.

2. Natural History: Bemushroomed

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3. History: The First Wave

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4. Travelogue: Journeying Underground

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5. The Neuroscience: Your Brain on Psychedelics

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6. The Trip Treatment: Psychedelics in Psychotherapy

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Epilogue: In Praise of Neural Diversity

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